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Antibiotic therapy in severe COVID-19 between march 2020 and july 2022 and correlations with outcome in an intensive care unit in central Italy
1
University of Molise Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Italy; School of Specialization in Hygiene and Preventive Medicine, University of Molise, Italy; Regional Health Agency of Molise region, Italy Italy
2
University of Molise
3
University of Molise School of Specialization in Hygiene and Preventive Medicine, University of Molise, Italy Italy
4
University of Molise Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Italy Italy
Publication date: 2023-04-26
Popul. Med. 2023;5(Supplement):A535
ABSTRACT
Background and Objective:
Covid-19 can evolve into severe clinical manifestations requiring hospitalization in intensive care unit (ICU) where antibiotic therapy is extensively undertaken. Antimicrobials use was evaluated in relation to the outcomes (transfer in other wards/death) in COVID-19 patients in ICU between May 2020-July 2022 in Molise region, central Italy.
Methods:
Data were obtained from clinical records and internal ward software. A descriptive and univariate analysis was performed through SPSS v28.0 setting p2 antibiotics, and a significant relation with outcome was observed, as 86% and 98% deaths occurred among who took ≤2 and >2 antibiotics, respectively. Further differences were found between outcome and treatment with azithromycin, meropenem, ceftaroline, linezolid and teicoplanin. Polypharmacotherapy with ≥3 antibiotics was more common in male patients (81.3% vs 18.7%), while no differences with respect of age
Covid-19 can evolve into severe clinical manifestations requiring hospitalization in intensive care unit (ICU) where antibiotic therapy is extensively undertaken. Antimicrobials use was evaluated in relation to the outcomes (transfer in other wards/death) in COVID-19 patients in ICU between May 2020-July 2022 in Molise region, central Italy.
Methods:
Data were obtained from clinical records and internal ward software. A descriptive and univariate analysis was performed through SPSS v28.0 setting p2 antibiotics, and a significant relation with outcome was observed, as 86% and 98% deaths occurred among who took ≤2 and >2 antibiotics, respectively. Further differences were found between outcome and treatment with azithromycin, meropenem, ceftaroline, linezolid and teicoplanin. Polypharmacotherapy with ≥3 antibiotics was more common in male patients (81.3% vs 18.7%), while no differences with respect of age
| ISSN: | 2654-1459 |
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