Background:
Several studies have shown that antibody responses in people with HIV depend on CD4 count and people with HIV with CD4 counts below 500 may have a weaker response to vaccination. This systematic review aims at evaluating vaccine effectiveness reported by real world studies on HIV patients.

Material and Methods:
PubMed, medRxiv/bioRxiv, WHO covid-19 databases, the VIEW-hub platform and the 2022 CROI (Conference on Retroviruses and Opportunistic Infections) site were searched using the terms “COVID-19″, “SARS-CoV-2″, “vaccine efficacy”, “people living with HIV”.

Results:
Real world studies were conducted in Zambia [3], Taiwan [4], South Africa [5], and the Russian Federation [6]. Vaccine effectiveness estimates ranges varied widely across included studies according to the outome considered: - infection: 65,8 [6]- 100% [4] - severe disease/hospitalization/ICU admission: 73,2 - 79,3% [5] - death/in-hospital mortality: 67,2 [5] - 76,0 % [3] Vaccine effectiveness author outcome hiv+ Vaccinated hiv+ unvaccinated ve% 95CI events total %95CI events total %95CI gushchin infection 71 2543 2,3 (2,2 - 3,5) 1354 16606 8,2 (6,1 - 8,6) 65,8(56,7 -72,9) LIN infection 0 336 0(0 – 1,1) 37 2795 1,3 (0,9 - 1,8) 100 bekker hospitalization 18 3802 0,5(0,3 - 0,8) 66 3731 1,8 (1,4 - 2,3) 73,2(55,0-84,1) bekker ICU admission 4 3802 0,1 (0,0 -0,3) 19 3736 0,5(0,3 - 0,8) 79,3 (93,0-99,9) bekker death 5 3803 0,1 (0,0 -0,3) 15 3738 0,4 (0,2 - 0,6) 67,2 (9,9-88,1) hines in-hospital mortality 17 159 5,8(3,4 – 9,1) 295 1229 24,0(21,6 - 26,5) 76,0(61,5 - 85,0)

Conclusions:
Taken together, the available evidence shows that PLWHA are protected by current WHO recommended COVID-19 vaccines.