Efficacy of low-level laser therapy in reducing local manifestations of bothrops atrox envenomations: a randomized clinical trial
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Universidade do Estado do Amazonas, Brazil
Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Brazil
Publication date: 2023-04-26
Popul. Med. 2023;5(Supplement):A1781
Antivenom is the only treatment that neutralizes the systemic effects of snake venoms. For local results, the inflammatory process of residual tissue damage remains. Laboratory research directs the use of laser therapy as a regenerative option for tissues. To evaluate the use of low-level laser in sites with the presence of Bothrops venom to minimize skin damage, reduce inflammatory effects, and reduce myonecrosis.

The phase II A clinical trial was randomized and double-blind performed in patients who had bothropic accidents from May 2020 to March 2022, coming from Tropical Medicine Foundation Doctor Heitor Vieira Dourado. The study was carried out with 60 patients divided into 2 groups: 1. Control; 2. Those who Received laser 30 minutes after antivenom. The laser was applied to the skin lesions at 24, 48, and 72 hours in both groups at a dose of 4j/cm2, to the extent shown by thermography, in placebo with the device turned off. As outcomes, a 53.0% decrease in CK was obtained in the laser group while the control group increased by 35.0%, with p=0.03, thus evaluating myonecrosis.

As for the outcomes of inflammatory signs, this clinical trial showed a decrease in pain on the third day of 33.0% in the control group, while the laser group decreased by 66.0%, with a significance of p=0.001. Edema in extension measures decreased in the laser group by 21.0%, and in the control group, there was an increase of 15%, p=0.006. As for the circumference of the edema, the control group had an increase of 23% while the group that received the laser treatment showed a decrease of 29%, p = 0.018.

The effects of low-level laser were positive in reducing the local pathological effects caused by snake venom of the Bothrops atrox genus and accelerating myotoxicity-related tissue regeneration.