Background and Objectives: Mental disorders are common in the community, can become chronic, result in disability, decrease academic achievement, and often cannot be adequately treated because they are not noticed. For this reason, mental disorders are a public health problem that concerns not only the individual but also the society and has a high cost. In this study, it was aimed to evaluate the students of Eskişehir Osmangazi University (ESOGÜ) Faculty of Medicine in terms of mental disorders. Methods: This cross-sectional study was conducted on 742 ESOGU Medical Faculty students between 2021-2022. The Self-Report Scale (SRQ) and the General Health Questionnaire (GHQ) were used to assess the participants' mental disorders. An online questionnaire form was prepared and distributed to students. Mann Whitney U, Kruskal Wallis, and Spearman correlation analysis were used. Results: Of the study group, 376 (50.7%) were women, and the mean age was 21.03 ± 2.05 years. The mean score of the SRQ was 7.02 ± 5.22. Being women, worsening income, living alone, having a history of mental disorder, chronic illness, experiencing significant trauma, and not getting enough social support increase the probability of experiencing a mental disorder. It was determined that there was a strong positive correlation between SRQ and GHQ scores (p<0.001, r=0.740). Conclusions: The probability of experiencing a mental disorder was low in the study group. Gender, economic conditions, living conditions, family history of mental disorder, chronic illness, life traumas and social supports predicted the probability of mental disorder. Influencing individuals trained in the field of health can lead to significant disruptions in the health system when they are involved. For this reason, individuals at risk should be identified and necessary preventive and therapeutic interventions should be applied.