Factors associated with tuberculosis preventive treatment incompletion: a retrospective Cohort.
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Universidade Federal do Espirito Santo, Post-graduate Program in Saúde Coletiva Brazil
Federal University of Rio de Janeiro, Brazil
Universidade Fedeal Do Espírito Santo Brazil
Universidade Federal do espírito Santo Brazil
Pan American Health Organization - Brazil Brazil
Universidade Federal do Rio de Janeiro Brazil
Johns Hopkins University United States
Publication date: 2023-04-26
Popul. Med. 2023;5(Supplement):A1946
Among Brazilian initiatives to scale up preventive treatment of tuberculosis (TPT) are the adoption of the 3HP regimen in 2021 and the implementation in 2018 of the TPT surveillance information system. Since then, among 76,000 TPT were notified, 63% completed. Recommended regimens in this period were 6H, 9H and 4R. The objective was to analyze the factors associated with TPT non-completion.

We analyzed the cohort of TPT notifications from 2018 to 2020. Individuals with current or past TB disease,deaths and transferred to another country were excluded. Robust variance Poisson regression model was used to verify the association of TPT non-completion with sociodemographic, clinical and epidemiological variables.Results of the multivariate analysis were interpreted as relative risk (RR) with a 95% confidence interval (95%CI).

Out of 39,973 TPT notified in the study period, 8,534 (21.5%) were non-completed, of which 7,858 (92.08%) were loss to follow up. Age 15-60 (RR=1.27, 1.20-1.35), TPT with isoniazid (RR=1.40, 1.19-1.64) and black/mixed race (RR=1.17, 1.09-1.25) were associated with a higher risk of non68 completion. 69

Individuals in social and financial vulnerability such as 70 black/pardo race and young adults and longer TPT regimens are more likely to TPT incompletion.