The acute toxicity, antimicrobial and anti-inflammatory profile of the ethanolic and acetone extract of the leaves Teclea Nobilis
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Addis Ababa University, Addis Ababa, Ethiopia
Publication date: 2023-04-27
Popul. Med. 2023;5(Supplement):A105
Teclea Nobilis, is a medicinal plant which is believed to have anti-inflammatory and antipyretic properties. In this study, the acute toxicity, the antimicrobial, and the anti-inflammatory profile of the plant are reported. One group served as a control and the other three groups received the different concentrations of the plant extract. 2000mg/kg, 1500mg/kg and 1000mg/kg were used. Weight, % PCV and liver biopsy were done at the end of the study to determine toxicity. All the mice showed increased weight throughout the study period. The % PCV measured at the start and end of the study showed decreased values from the time of the start of the study. The liver biopsy also showed some changes consistent with acute toxicity. For this reason, we recommend caution be taken in use of the plant especially in susceptible population. Staphylococcus Epidermidis, Enterococcus Faecalis, Salmonella Typhi and Listeria Monocytogenes were used as test bacteria for the antimicrobial study. Varying doses of the plant extract were used for the test which are 500mg/ml, 450mg/ml and 300mg/ml. The results shows the ethanolic/acetone plant extract has no antibacterial activity towards S. Epidermidis, E. Faecalis and L. Monocytogenes. Nevertheless, it was determined that it has moderate activities toward S. Typhi. And we recommend larger scale study be done to determine dosage and associated side effects with the plant. The anti-inflammatory testing was done on 30 mice which were divided in five groups. One group served as the control and received Normal Saline (NS) while the other three groups received different and increasing doses of the plant extract (600mg/kg, 400mg/kg and 200mg/kg) and the last group served as a negative control and only received NS. It was concluded the plant has some anti-inflammatory activity on higher doses. Based on this study we have recommended a largescale study be done.