Background: Bulgaria is one of the countries with the highest level of ageing using the share of people over 65 years of age /22% for 2022/ - on the eighth position in the world ranking. The population ageing in Bulgaria is one of the most significant demographic problems nowadays. The level of ageing in different regions of Bulgaria has varied values. This report Aims to investigate and conduct a comparative analysis of indicators of the death rate due to COVID-19 and population ageing in 2021 in Bulgaria.  Methods: The regional indicators for ageing and mortality due to COVID-19 were analysed based on the National Statistical Institute data. The absolute numbers were regrouped and the main indicators for population ageing were calculated. Analysis and calculations were performed by MS Excel 2019. Data have been statistically processed with SPSS v.24. To establish the relationship between death rates and ageing, Pearson’s correlation coefficient has been used. Results: The study found that the death rate due to COVID-19 in Bulgaria for 2021 is 401.12 per 100000 population but there are six regions where the level of the indicator is above 500 – Silistra, Vratsa, Gabrovo, Montana, Vidin, and Kyustendil. Kyustendil, Gabrovo, and Vidin are the regions with the highest level of ageing in our country - respectively 27.77%, 29.11%, and 29.69%, the level for the country is 21.67%. The statistical analysis shows that there is a positive correlation between ageing and death rate due to COVID – 19, The Pearson coefficient is 0.503. Conclusions: The regional health inequalities in Bulgaria are very important in order to control and decrease the level of mortality in the country especially the death rate due to COVID-19.