Analysis of Risk Factors for Upper Gastrointestinal Cancer and Precancerous Lesions in High-Risk Populations Aged 40–69 in Chaoshan Region of Guangdong Province, China
1
School of Public Health, Shantou University,Shantou, Guangdong, China, School of Public Health, Shantou University, Shantou, China
2
Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China, Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University Medical College, Shantou, China
3
Department of Orthopedics, the Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China, Department of Orthopedics, the Cancer Hospital of Shantou University Medical College, Shantou, China
Popul. Med. 2026;8(Supplement Supplement 1):
ABSTRACT
INTRODUCTION:
Nearly half of the upper gastrointestinal cancers worldwide occur in China. In China, screening coverage shows a 'higher in the north, lower in the south' pattern. As the only national prospective cohort site for esophageal cancer in South China, the epidemiological characteristics of the disease in the Chaoshan region remain unclear. The purpose of this study isTo analyze the risk factors for upper gastrointestinal cancers and precancerous lesions in the Chaoshan region, providing a basis for targeted regional prevention and control.
METHODS:
From March 2019 to October 2025, a retrospective case-control study was conducted on high-risk individuals aged 40–69 in Chaoshan. The target sample collected valid data from 2,273 cases. Logistic regression was used to analyze 17 independent variables.
RESULTS:
The prevalence of upper gastrointestinal cancer and precancerous lesions was 16.41% (373/2,273). Univariate analysis showed that 10 factors were associated with disease risk (P<0.05). Multivariate analysis indicated that being male (OR=1.608, 95% CI: 1.169–2.211), age groups 45–69 years (reference 40–44 years, OR=2.055–2.799), alcohol consumption (OR=1.511, 95% CI: 1.189–1.920), and households with ≥8 members (OR=1.970, 95% CI: 1.103–3.519) were independent risk factors; households with 4–7 members (OR=0.749, 95% CI: 0.569–0.984) and consumption of meat, eggs, dairy, and legumes (OR=0.096–0.585) were independent protective factors (all P<0.05).
CONCLUSIONS:
The detection rate of upper gastrointestinal cancers and precancerous lesions in the Chaoshan region is relatively high. Screening efforts should focus on high-risk groups such as men, the elderly, alcohol consumers, and large families. It is recommended to advocate for a balanced intake of meat, eggs, dairy, and legumes, and to develop differentiated prevention and control strategies based on age and family structure, in order to improve regional prevention and control effectiveness. Keywords:upper gastrointestinal cancer, risk factors, precancerous lesions, Chaoshan region
Nearly half of the upper gastrointestinal cancers worldwide occur in China. In China, screening coverage shows a 'higher in the north, lower in the south' pattern. As the only national prospective cohort site for esophageal cancer in South China, the epidemiological characteristics of the disease in the Chaoshan region remain unclear. The purpose of this study isTo analyze the risk factors for upper gastrointestinal cancers and precancerous lesions in the Chaoshan region, providing a basis for targeted regional prevention and control.
METHODS:
From March 2019 to October 2025, a retrospective case-control study was conducted on high-risk individuals aged 40–69 in Chaoshan. The target sample collected valid data from 2,273 cases. Logistic regression was used to analyze 17 independent variables.
RESULTS:
The prevalence of upper gastrointestinal cancer and precancerous lesions was 16.41% (373/2,273). Univariate analysis showed that 10 factors were associated with disease risk (P<0.05). Multivariate analysis indicated that being male (OR=1.608, 95% CI: 1.169–2.211), age groups 45–69 years (reference 40–44 years, OR=2.055–2.799), alcohol consumption (OR=1.511, 95% CI: 1.189–1.920), and households with ≥8 members (OR=1.970, 95% CI: 1.103–3.519) were independent risk factors; households with 4–7 members (OR=0.749, 95% CI: 0.569–0.984) and consumption of meat, eggs, dairy, and legumes (OR=0.096–0.585) were independent protective factors (all P<0.05).
CONCLUSIONS:
The detection rate of upper gastrointestinal cancers and precancerous lesions in the Chaoshan region is relatively high. Screening efforts should focus on high-risk groups such as men, the elderly, alcohol consumers, and large families. It is recommended to advocate for a balanced intake of meat, eggs, dairy, and legumes, and to develop differentiated prevention and control strategies based on age and family structure, in order to improve regional prevention and control effectiveness. Keywords:upper gastrointestinal cancer, risk factors, precancerous lesions, Chaoshan region
| eISSN: | 2654-1459 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
