Assessing antimicrobial susceptibility profiles among enterobacterales isolates: a case study of lekma hospital
1
Public Health and Research Unit, LEKMA Hospital, Accra, Ghana
2
Microbiology Laboratory, LEKMA Hospital, Accra, Ghana
3
Paediatrics Department, LEKMA Hospital, Accra, Ghana
4
Emergency Department, LEKMA Hospital, Accra, Ghana
5
Community Health Department, Korlebu Teaching Hospital, Accra, Ghana
Popul. Med. 2026;8(Supplement Supplement 1):
ABSTRACT
INTRODUCTION:
The emergence of drug-resistant organisms, both in healthcare settings and the community, poses a significant challenge for healthcare providers. Among these organisms, Enterobacterales, including Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis, are of particular concern due to their prominent roles in both community and hospital-acquired infections. The study aimed to evaluate the antimicrobial susceptibility profiles of Enterobacterales isolates and determine the prevalence of antimicrobial resistance (AMR) among patients at lekma hospital.
METHODS:
Conducted from september 2022 to july 2023, the study involved collecting and examining 688 clinical samples (503 from females and 185 from males) for bacterial cultures using standard procedures. Samples were cultured on various media to isolate and identify bacterial species and assess their susceptibility.
RESULTS:
Antimicrobial susceptibility testing (AST), following clinical and laboratory standards institute (CLSI) guidelines, revealed an overall resistance rate of 42.6% among the isolated pathogens. Notably, Escherichia coli, the most frequently isolated pathogen, demonstrated a 44.3% resistance rate, with significantly higher resistance in males (48.5%) compared to females (43.3% p = 0.0447). Similar trends of higher male resistance were seen in Pseudomonas aeruginosa (49.4% vs. 44.4%) and Klebsiella spp. (45% vs. 37.9% p = 0.0137). Conversely, Staphylococcus aureus showed higher resistance in females (41.3%) than males (37.4%, p = 0.0320). Minimum inhibitory concentration (MIC) data indicated alarming resistance to conventional beta-lactams but highlighted the effectiveness of newer combination therapies.
CONCLUSIONS:
The findings reveal a high rate of AMR at lekma hospital, marked by significant gender-based differences and declining efficacy of beta-lactam treatments. While traditional antibiotics face increasing resistance, the effectiveness of novel combination therapies presents a crucial alternative for clinical management. This underscores the need for gender-responsive antimicrobial stewardship and the integration of advanced susceptibility testing to address the rising challenge of drug-resistant infections.
The emergence of drug-resistant organisms, both in healthcare settings and the community, poses a significant challenge for healthcare providers. Among these organisms, Enterobacterales, including Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis, are of particular concern due to their prominent roles in both community and hospital-acquired infections. The study aimed to evaluate the antimicrobial susceptibility profiles of Enterobacterales isolates and determine the prevalence of antimicrobial resistance (AMR) among patients at lekma hospital.
METHODS:
Conducted from september 2022 to july 2023, the study involved collecting and examining 688 clinical samples (503 from females and 185 from males) for bacterial cultures using standard procedures. Samples were cultured on various media to isolate and identify bacterial species and assess their susceptibility.
RESULTS:
Antimicrobial susceptibility testing (AST), following clinical and laboratory standards institute (CLSI) guidelines, revealed an overall resistance rate of 42.6% among the isolated pathogens. Notably, Escherichia coli, the most frequently isolated pathogen, demonstrated a 44.3% resistance rate, with significantly higher resistance in males (48.5%) compared to females (43.3% p = 0.0447). Similar trends of higher male resistance were seen in Pseudomonas aeruginosa (49.4% vs. 44.4%) and Klebsiella spp. (45% vs. 37.9% p = 0.0137). Conversely, Staphylococcus aureus showed higher resistance in females (41.3%) than males (37.4%, p = 0.0320). Minimum inhibitory concentration (MIC) data indicated alarming resistance to conventional beta-lactams but highlighted the effectiveness of newer combination therapies.
CONCLUSIONS:
The findings reveal a high rate of AMR at lekma hospital, marked by significant gender-based differences and declining efficacy of beta-lactam treatments. While traditional antibiotics face increasing resistance, the effectiveness of novel combination therapies presents a crucial alternative for clinical management. This underscores the need for gender-responsive antimicrobial stewardship and the integration of advanced susceptibility testing to address the rising challenge of drug-resistant infections.
| eISSN: | 2654-1459 |
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