Association between multimorbidity and early-onset dementia and mild cognitive impairment in adults aged 50-64: Evidence from the Brazilian Longitudinal Study of Aging - Brazil (ELSI-Brazil) study .
1
1. Postgraduate Program in Health Sciences, Medical School, Federal University of Goiás, Goiânia, Brazil
2
2. Department of Epidemiology & Public Health, University College London, London, United Kingdom
Popul. Med. 2026;8(Supplement Supplement 1):
ABSTRACT
BACKGROUND:
Among middle-aged adults, the association between multimorbidity and mild cognitive impairment (MCI) and young-onset dementia remains underexplored. Therefore, this study aimed to investigate the association between multimorbidity and young-onset dementia and MCI among adults aged 50 to 64 years.
METHODS:
This is a population-based cross-sectional study using data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil, 2015-2016), representing urban and rural residents across Brazil's five macro-regions. The study included 4815 participants aged 50-64. Multimorbidity was defined as the presence of ≥2 out of 17 chronic conditions. Bivariate analyses and Poisson regression were used to calculate Prevalence Ratios (PR) with 95% confidence intervals and a significance level of p < 0.05. Analyses were performed in Stata, accounting for the complex sample design.
RESULTS:
The prevalence of multimorbidity was 73.89%, with 7.69% among those with CCL (PR: 1.08; 95% CI: 0.84-1.40; p=0.510) and 2.5% among those with early-onset dementias (PR=1.79; 95% CI: 1.03-3.12; p=0.034). In sex-stratified analysis, multimorbidity prevalence in women was 8.26% for MCI (PR: 1.16; 95%CI: 0.82-1.66; p=0.379) and 2.29% for early-onset dementia (PR: 1.96; 95%CI: 0.83-4.60; p=0.113). Among men, prevalence was 6.76% for MCI (PR: 0.95; 95%CI: 0.65-1.39; p=0.820) and 2.83% for early-onset dementia (PR: 1.77; 95%CI: 0.85-3.69; p=0.118).
CONCLUSIONS:
Multimorbidity was highly prevalent among adults aged 50-64. It was significantly associated with early-onset dementia but not with MCI. No significant associations were observed in sex-stratified analyses. Future studies should further investigate these links to enhance prevention strategies.
Among middle-aged adults, the association between multimorbidity and mild cognitive impairment (MCI) and young-onset dementia remains underexplored. Therefore, this study aimed to investigate the association between multimorbidity and young-onset dementia and MCI among adults aged 50 to 64 years.
METHODS:
This is a population-based cross-sectional study using data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil, 2015-2016), representing urban and rural residents across Brazil's five macro-regions. The study included 4815 participants aged 50-64. Multimorbidity was defined as the presence of ≥2 out of 17 chronic conditions. Bivariate analyses and Poisson regression were used to calculate Prevalence Ratios (PR) with 95% confidence intervals and a significance level of p < 0.05. Analyses were performed in Stata, accounting for the complex sample design.
RESULTS:
The prevalence of multimorbidity was 73.89%, with 7.69% among those with CCL (PR: 1.08; 95% CI: 0.84-1.40; p=0.510) and 2.5% among those with early-onset dementias (PR=1.79; 95% CI: 1.03-3.12; p=0.034). In sex-stratified analysis, multimorbidity prevalence in women was 8.26% for MCI (PR: 1.16; 95%CI: 0.82-1.66; p=0.379) and 2.29% for early-onset dementia (PR: 1.96; 95%CI: 0.83-4.60; p=0.113). Among men, prevalence was 6.76% for MCI (PR: 0.95; 95%CI: 0.65-1.39; p=0.820) and 2.83% for early-onset dementia (PR: 1.77; 95%CI: 0.85-3.69; p=0.118).
CONCLUSIONS:
Multimorbidity was highly prevalent among adults aged 50-64. It was significantly associated with early-onset dementia but not with MCI. No significant associations were observed in sex-stratified analyses. Future studies should further investigate these links to enhance prevention strategies.
| eISSN: | 2654-1459 |
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