BACKGROUND:
The intertwined challenges of global ecological health and zoonotic risks indicate room for the evolution of traditional public health “barrier” models, which focus on containment and response but have limitations in addressing the ecological root causes of disease. Given that approximately 75% of emerging infectious diseases are zoonotic, it is imperative to advance the public health paradigm towards a more proactive and inclusive vision that incorporates the well-being of ecosystems and future generations.

METHODS:
We propose an ethics-driven “Bridge” paradigm. Reports have indicated that in similar ecological intervention practices in pastoral regions of Western China, a reduction of approximately 37% in reported zoonotic cases was observed. The paradigm is articulated through a three-tiered framework: 1) establishing foundational ecological restoration as the primary defense; 2) supporting it with cross-sectoral surveillance; and 3) reserving targeted emergency responses as a last resort. We outline a planned three-year comparative implementation study to test the efficacy, adaptability, and replicability of this framework across pastoral systems in Western China and South Africa. Results and

CONCLUSIONS:
The study aims to systematically evaluate and quantify the framework's multifaceted outcomes, including improvements in ecological baselines, reductions in high-risk human-animal contact, decreases in zoonotic spillover rates, and enhanced inter-sectoral coordination efficiency. This paradigm transcends anthropocentric elimination mindsets, offering a replicable and practical blueprint for health governance. We conclude that this “Bridge” model provides a critical pathway toward a more resilient, equitable, and sustainable global health future, safeguarding well-being for all life, present and future.