Effectiveness of vaccination on hospitalisation related outcomes: a population-cased study in Northern Italy
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University of Modena and Reggio Emilia Department of Biomedical, Metabolic and Neural Sciences Via Campi 287, 41125 Modena, Italy Italy
University of Modena and Reggio Emilia
South Tyrol Health Care Service Epidemiological Surveillance Unit Via Lorenz Böhler 5, 39100, Bolzano, Italy Italy
South Tyrol Health Care Service Medical Management Via Lorenz Böhler 5, 39100, Bolzano, Italy Italy
South Tyrol Health Care Service General Management Via Thomas Alva Edison 10/D, 39100, Bolzano, Italy Italy
Publication date: 2023-04-26
Popul. Med. 2023;5(Supplement):A441
Background and objective:
Although the efficacy of SARS-CoV-2 vaccines in preventing severe disease – especially in older adults – is widely demonstrated, there are not many studies conducted in the Alps with large sample sizes and during Omicron variant period. Moreover, scarce literature analyses the hospitalisation length of SARS-CoV-2 patients and its association with vaccination status. Aim of this study is to investigate the associations between ordinary or intensive care unit (ICU) hospitalisations and the vaccination status of SARS-CoV2 adult patients resident in the Italian alpine province of Bolzano.

We collected anonymized data from 93643 patients who swabbed positive for SARS-CoV-2 between November‘21 and February’22 – coinciding with the arrival of the Omicron variant. Associations between vaccination status and hospitalisation characteristics were assessed using bivariate statistics and multiple logistic regression.

Of 93643 positive patients, 925 were hospitalised (90% ordinary ward, 10% ICU). Among over 65 (8% of the sample and 68% of hospitalisations), vaccinated patients had a significantly lower risk of being admitted to ordinary wards compared to not vaccinated: Odds Ratio(OR)=0.40(CI:0.35-0.48); to ICU: OR=0.26(CI:0.15-0.47) and to die: OR=0.39(CI:0.29-0.52). These risks were even lower for vaccinated with booster compared to unvaccinated. Suggestively, also among vaccinated patients those with booster showed decreased risk of hospitalisation: OR=0.54(CI:0.42-0.67); and death: OR=0.39(CI:0.25-0.61). Similar associations were found in age range 30-65. Finally, average duration of ICU stay was significantly longer for unvaccinated people compared to vaccinated (9-6 days; p

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