INTRODUCTION:
Most emerging and re-emerging infectious diseases are zoonotic, underscoring the importance of close links between human, animal, and environmental health[1,2]. In Nigeria, the risk of zoonotic spillover is intensified by deforestation, rapid urbanization, wildlife trade, and livestock intensification[3,4]. The COVID-19 pandemic highlighted the urgency of integrated, multi-sectoral approaches for preparedness, detection, and response[5,6]. Context &

AIM:
Study applies the One Health Strategic Framework to Kaduna State, examining collaboration across human, animal, and environmental health sectors in preventing, detecting, and mitigating zoonotic threats/outbreaks. The objectives are to assess existing capacities, document best practices, and identify systemic barriers constraining effective implementation[7].

METHODS:
Review of Kaduna State surveillance data and outbreak reports was conducted, focusing on zoonotic diseases and multi-sectoral response mechanisms[8].

RESULTS:
Revealed progress in community-based surveillance, improved multi-sector collaboration and coordination, which enhanced early detection and response in line with the 7-1-7 benchmark[9]. However, persistent gaps are; fragmented data systems, inadequate funding, and weak enforcement of policies[10,11]. Integrating One Health principles into state and national health security strategies is essential to reduce zoonotic risks[12]. Innovative Contribution: Demonstrates how state-level One Health integration can be operationalized to strengthen multi-sector collaboration, coordination, and communication, thereby improving emergency preparedness and response in Nigeria[13].