Polymorphisms in miRNA biogenesis genes and the risk of pregnancy-induced hypertension among Jordanian women
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Jordan University of Science and Technology, Jordan
Publication date: 2023-04-27
Popul. Med. 2023;5(Supplement):A1066
Background and Objective: Pregnancy-induced hypertension (PIH) includes gestational hypertension and pre-eclampsia. PIH might be associated with severe pregnancy outcomes. Non-genetic factors such as advanced age, high body mass index (BMI), and diabetes are significant risk factors for PIH. At the genetic level, some studies showed that single nucleotide polymorphism (SNP) in miRNA biogenesis genes such as DICER and RAN are associated with PIH. In the current study, the contribution of DICER (rs3742330) and RAN (rs14035) to PIH in Jordan was investigated. Methods: A total of 250 Jordanian pregnant women with (n=99) or without (n=145) PIH were recruited into the study. The rs3742330 and rs14035 were genotyped using molecular techniques. Non-genetic factors were examined using a structured questionnaire. Blood measurements were performed on all participants and were correlated with the different genotypes of studies SNPs. Results: The frequency of rs3742330 genotypes among the study sample was 76%, 21%, 2% for AA, GA, GG respectively. The frequency of rs14035 genotypes among the study sample was 59.6%, 35.4%, 5% for CC, CT, TT respectively. An association was found between rs3742330 and PIH (P<0.05). The frequency of G allele and AG/GG genotypes were enriched in the PIH group compared to the control group (P<0.05). On the other hand, no association was found between rs14035 and PIH (P>0.05). With respect to environmental factors, BMI was found to be associated with a higher risk of PIH (P<0.001. None of the examined SNPs were associated with hematological parameters (P>0.05). Conclusions: DICER rs3742330 and BMI were associated with PIH among pregnant women in Jordan. These factors should be considered in interventions that target PIH management in the country.
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Birth Defects Research
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