Sinonasal intestinal type adenocarcinoma: increased incidence in Portuguese woodworkers
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Public Health Resident at Baixo Tâmega Public Health Unit, Portugal
Tâmega e Sousa Hospital Center, Portugal
Publication date: 2023-04-27
Popul. Med. 2023;5(Supplement):A1538
Background and Objective: Sinonasal carcinomas are rare, having an estimated world incidence of 0.5-1/100.000 individuals per year. Intestinal type adenocarcinoma (ITAC) account for 6-13% of these, but its incidence is around 1000 times higher among woodworkers, being recognized as an occupational disease. Our hospital serves a population of approximately 550.000 individuals, many of which are woodworkers. We aim to estimate the incidence of sinonasal ITAC in our area and to characterize the affected population. Methods: We did a retrospective cohort study of all the patients diagnosed with sinonasal ITAC, in the otorhinolaryngology department of a Portuguese tertiary level hospital, between January 2018 and December 2022, and performed a descriptive analysis. Results: In 5 years, 27 cases were diagnosed, 25 (93%) of which were or had been woodworkers. The median of ages was 64 years and 26 (96%) were men. In one of the two patients not exposed in the workplace, we could not find any link to wood dust, the other one had an husband that had a woodshop in their home. Nasal obstruction was the main cause of admission. The mean time between the first symptom and the diagnosis was 6 months, with 11 (41%) patients in stage T4. Conclusions: Based on the global incidence of sinonasal ITAC, our hospital should have less than 1 case per year. However, in 5 years we diagnosed 27 patients, most of which in advanced stage (T3 or T4). With that in mind, we are planning a collaborative public health intervention in the most affected cities and wood companies to build community resilience through health promotion, empowerment and literacy.
Sinonasal Adenocarcinoma: Clinicopathological Characterization and Prognostic Factors
Marta Baptista Freitas, Mariana Costa, Andreia Freire Coelho, Pedro Rodrigues Pereira, Manuel Leal, Cristina Sarmento, Lúcia Águas, Miguel Barbosa
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