Structural syndemics: from diagnosis to action on inequality, climate, and health sovereignty in Africa
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1 School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa
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2 Division of Public Health Surveillance and Response, National Institute for Communicable Diseases, Johannesburg, South Africa
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3 Environmental Health and Port Health, National Department of Health, Pretoria, South Africa
Popul. Med. 2026;8(Supplement Supplement 1):
ABSTRACT
ABSTRACT:
The defining problem for public health in Africa is the complex interaction between infectious disease threats, increasing burden for non-communicable diseases, climate-enhanced disasters, and deeply ingrained health disparities. Current strategies often treat these as distinct crises, resulting in disjointed, symptom-focused solutions that overlook the underlying social, political, and economic systems that consistently create vulnerability. When disasters strike, these forces interact as structural syndemics—mutually reinforcing systems based on gendered inequality, extractive political economies, and misaligned global financing architectures that systematically determine who is most vulnerable, who becomes ill, and who recovers. This organised session will present “Structural Syndemic Cycle" framework to clarify how political-economic processes create differential vulnerability, how disasters cause synergistic health crises, and how traditional solutions sustain cycles of dependency. Key questions: • How can the pillars of the Africa Health Security and Sovereignty (AHSS) agenda be used to eliminate systemic injustices that cause health disparities during disasters rather than to make accommodations for them? • How can financing for pandemic prevention and climate adaptation directly support community-led, gender-transformative health sovereignty amidst rising non-communicable disease burden? • In restructuring health and climate governance, how can African youth, the largest demographic and most impacted generation, be positioned as agents of structural change? Session format: The aim is to transform evidence of systemic injustices into a concrete agenda for transformative health sovereignty. • Utilize the "Structural Syndemic Cycle" model to show why the success of the AHSS Agenda rests on addressing the underlying political and economic causes of vulnerability. • Moderated discussion on practical levers, climate-resilient primary care, financing community-led, gender-transformative health systems, and positioning youth as agents of structural change. • This session will develop a "2026 Action Compact" as Africa's transformative sovereignty agenda, to outline how global climate finance and pandemic governance must be realigned.