Study on Depletion of ovarian function and Late-life chronic diseases in India
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Jawaharlal Nehru University, JNU Campus, New Mehraulli Road, New Delhi 110067, India
Publication date: 2023-04-26
Popul. Med. 2023;5(Supplement):A1490
Depletion of ovarian function which occurs due to menopause can affect multiple organs leading to multimorbidity. Women with extreme menopause ages (early or late) suffers from increased accumulated risk of multimorbidity than women who experience natural menopause. Hence, the study aims to understand the menopausal age in association which chronic conditions or multimorbidity.

The present study analyses the nationally representative data, Longitudinal Aging Study in India (LASI), 2017-2018, Wave 1. Bivariate analysis was carried out to examine the significant association between the covariates and the dependent variables which are the number of chronic diseases. Independent t-tests were used for continuous variables, and chi-square tests were used for categorical variables. Further regression analysis has been done to observe the effect of menopausal age on various chronic diseases, controlling the socio-economic and demographic variables, lifestyle and bio-physical factors.

The results show that 15.8% of the women experienced premature menopause (50). Women with premature or early menopausal age are at higher risk of developing more chronic diseases such as heart diseases, whereas late menopausal age showed risk of high cholesterol. Women who had premature menopause, showed elevated risk of psychiatric disease.

The findings depict the relation of early or late depletion of ovarian function through menopause leads to chronic health conditions. A significant amount of risk of developing chronic diseases has been observed in the case of premature or early menopause. The loss of estrogen levels at an early age cause an alteration on the functioning of the organ systems that leads to chronic health conditions. Comprehensive strategies in the form of lifestyle changes may regulate the hormonal levels and allow body to reach menopause at the right age.

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