Teratological effect of Levetiracetam (antiepileptic drug)  in utero on the foetus of albino mice
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North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS), India
Publication date: 2023-04-27
Popul. Med. 2023;5(Supplement):A1029
Aims and Objectives: Teratological effect of newly developed drugs is serious concern of practicing clinicians for pregnant women and as newly introduced antiepileptic drug Levetiracetam with limited teratological data, the respective study was undertaken with Aims of 1.to study effect of Levetiracetam on fetal growth of fetuses of albino mice 2.to study gross teratological effects of Levetiracetam on skeletal system of fetuses of albino mice and placenta Materials and methods: 40 female mice were taken for this study and divided into 4 groups with 10 female mice each and Group I is taken as controlled group and administered with distilled water intraperitoneally . Group II , GroupIII, GroupIV administered with escalated doses of Levetiracetam with drug concentration of 600mg/Kg, 1200mg/Kg ,1800mg/Kg respectively ,intraperitoneally and then anthropometric measurements of mice fetuses and placenta were taken , skeleton of mice fetuses  were studied with Alzerine Red S stain for bone malformations .Findings were analyzed using Annova variance testing and arcsine transformation followed by χ2 analysis with a Tukey-type q test and P value was calculated. Results and observations: No significant gross external malformations of albino mice fetuses  were observed in any of Groups. The Results showed that Fetuses in Groups II were decreased and Group III,IV increased in weight and crown rump length ,weight of placenta is increased into Group III,IV but decreased into Group II and all fetuses in all treated groups showed deficient ossification in body of vertebra(coccyx) ,skull bones ,carpal, metacarpal ,tarsal and carpal bones. Conclusions: Levetiracetam is having teratological effect and adverse outcome on overall growth of fetuses of mice and further investigations, for identification of possible teratological effects of Levetiracetam as an antiepileptic drug is needed for ensuring its safe use in pregnant women in clinical practice.
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