Carbapenem-resistant E. coli with one health approach in East Africa: systematic review and meta-analysis
1
Medical Laboratory Science, Debere Berhan University, Debre Berhan, Ethiopia
2
Paediatrics and child health, Debre Berhan University, Debre Berhan, Ethiopia
Popul. Med. 2026;8(Supplement Supplement 1):A152
ABSTRACT
INTRODUCTION:
Bacterial infections are linked to one in eight global deaths, and mortality is high when the infection is due to carbapenem-resistant bacteria. Carbapenem-resistant E. coli is among the global serious and urgent threats. The aim of this study was to explore carbapenem-resistant E. coli with a one-health approach in East African countries.
METHODS:
This systematic review and meta-analysis study was done based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. The protocol of this study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration Identification: CRD42024626968).
RESULTS:
The pooled prevalence of carbapenem-resistant E. coli in East Africa among different interfaces (human, animal, environment, and food) is 12.7%. The environment (24.2%) found the predominant interface for carbapenem-resistant E. coli compared to other interfaces, 11.9% in human, 7.7% in food, and 4.2% in animal. The carbapenem-resistant E. coil prevalence decreased for 2021-2025 (12.6%) compared to 2015-2020 (13.5%). High prevalence was seen in Sudan (24.7%), Uganda (17.4%), and Ethiopia (9.9%). Carbapenem-resistant E. coli was found predominantly in environmental samples (24.2%) and various clinical samples (15.8%). Different resistance gene variants, including serine β-lactamases, metallo-β-lactamases, and oxacillinase, were found in 51.7% of the studies.
CONCLUSIONS:
Carbapenem-resistant E. coli is found to be prevalent and a potential future threat in East Africa. It needs multifaceted strategies, including regional integration beyond health policy, to mitigate the problem.
Bacterial infections are linked to one in eight global deaths, and mortality is high when the infection is due to carbapenem-resistant bacteria. Carbapenem-resistant E. coli is among the global serious and urgent threats. The aim of this study was to explore carbapenem-resistant E. coli with a one-health approach in East African countries.
METHODS:
This systematic review and meta-analysis study was done based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. The protocol of this study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration Identification: CRD42024626968).
RESULTS:
The pooled prevalence of carbapenem-resistant E. coli in East Africa among different interfaces (human, animal, environment, and food) is 12.7%. The environment (24.2%) found the predominant interface for carbapenem-resistant E. coli compared to other interfaces, 11.9% in human, 7.7% in food, and 4.2% in animal. The carbapenem-resistant E. coil prevalence decreased for 2021-2025 (12.6%) compared to 2015-2020 (13.5%). High prevalence was seen in Sudan (24.7%), Uganda (17.4%), and Ethiopia (9.9%). Carbapenem-resistant E. coli was found predominantly in environmental samples (24.2%) and various clinical samples (15.8%). Different resistance gene variants, including serine β-lactamases, metallo-β-lactamases, and oxacillinase, were found in 51.7% of the studies.
CONCLUSIONS:
Carbapenem-resistant E. coli is found to be prevalent and a potential future threat in East Africa. It needs multifaceted strategies, including regional integration beyond health policy, to mitigate the problem.
| eISSN: | 2654-1459 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
