Implementation of national tobacco control law (NTCL) in the university settings was found very poor in Bangladesh. This study aimed to depict the compliance status of the tobacco control law (TCL) of Bangladesh following the university setting approach. This cross-sectional study was carried out based on descriptive including a mixed method approach, among the 385 students (quantitative method), 10 teachers, and 10 administrative staff (qualitative method) of Northern University Bangladesh. Quantitative and qualitative data were collected through face-to-face and In-Depth Interviews (IDI) Methods. The ethical issue of the study was conformed according to the Declaration of Helsinki. Data analysis was done through both descriptive and inferential statistics. Logistic regression analysis was performed followed by a modeling procedure to find out the determinants for the non-satisfactory compliance on TCL. The study revealed non-satisfactory compliance with TCL among 56.4% of subjects who were strongly supported by the outcomes from the qualitative approach. Predominant non-satisfactory compliance was found to explore the conditions of buying and selling tobacco (78.4%), pasting no-smoking signage (3.2%), anti-tobacco advertisement within the university (34.8%), and specific university policy to implement NTCL. Poor compliance was found significant among the younger aged (≤21 years: COR/p=2.74/0.01; 95% CI: 1.27-5.92) 1st-year group (AOR/P=2.28/0.02; 95% CI: 1.15-4.49) who had moderate nicotine dependency (AOR/P=4.04/0.01; 95% CI: 1.28-12.74) and poor knowledge on TCL (AOR/P=3.57/0.02; 95% CI: 1.28-9.95). As a predictor, a significant influential group suggested family guidance (AOR/P=1.77/0.06; 95% CI: 0.97-3.22) as a sustainable way to minimize tobacco consumption and improve compliance status among university students. This study revealed a depressive scenario on the compliance status of TCL in all tiers of the selected university setting. As it is a unique exploration of individual institutional compliance it might provide guidance to plan for sustainable intervention programs in order to improve compliance with TCL in university settings.